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Other gene therapies for medical conditions have shown a risk for this and other toxic side effects

36 Air Force SBIR Briefing for NRC Staff, June 2013

The stretching frequency of PL188 for hydroxyl group was observed at 2874.8 cm 1 , methyl group exhibited the stretching frequency at 1461.9 cm 1 and the stretching frequency for the C-O-C moiety was seen at 1094.9 cm 1

The evolution of GSH in aging fibroblasts showed a sudden increase in its concentration just before cell death, whereas GPx activity was already decreasing at the beginning of passages, and that of glutathione reductase was constant and reaching a very low level at the end of the cell culture, suggesting that the GSH system was probably involved in cell degeneration associated with aging [18]